Article

Global proteome metastability response in isogenic animals to missense mutations and polyglutamine expansions in aging

2022-09-28

Abstract excerpt

<h4>ABSTRACT</h4> The conformational stability of the proteome has tremendous implications for the health of the cell and its capacity to determine longevity or susceptibility to age-associated degenerative diseases. For humans, this question of proteome conformational stability has the additional complexity from non-synonymous mutations in thousands of protein coding genes challenging the capacity of the proteos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9dd190ca-d399-5e80-8a0a-6c6dc5bda4a4
DOI: 10.1101/2022.09.28.509812

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Global proteome metastability response in isogenic animals to missense mutations and polyglutamine expansions in agingDOI 10.1101/2022.09.28.509812Read

Progressive disruption of cellular protein folding in models of polyglutamine diseases.Semantic proximity Read

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.Semantic proximity Read

Proteostasis and longevity: when does aging really begin?Semantic proximity Read

Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in <i>C. elegans</i> via degradation of Intrinsically Disordered ProteinsSemantic proximity Read

Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in <i>C. elegans</i>Semantic proximity Read

Amyloid β accelerates age-related proteome-wide protein insolubilitySemantic proximity Read

Heterogeneity in heat shock response dynamics caused by translation fidelity decline and proteostasis collapseSemantic proximity Read

Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease.Semantic proximity Read

The stress of protein misfolding: from single cells to multicellular organisms.Semantic proximity Read

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by agingSemantic proximity Read

PRO-FitS: a novel phenotypic assay to identify enhancers of proteostasis in <i>C. elegans</i>Semantic proximity Read