Article
Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease.
Cell reports - 13 Sept 2016
Visscher Marieke, De Henau Sasha, Wildschut Mattheus H E, van Es Robert M, Dhondt Ineke, Michels Helen, Kemmeren Patrick, Nollen Ellen A, Braeckman Bart P, Burgering Boudewijn M T, Vos Harmjan R, Dansen Tobias B
Abstract excerpt
The balance between protein synthesis and protein breakdown is a major determinant of protein homeostasis, and loss of protein homeostasis is one of the hallmarks of aging. Here we describe pulsed SILAC-based experiments to estimate proteome-wide turnover rates of individual proteins. We applied this method to determine protein turnover rates in Caenorhabditis elegans models of longevity and Parkinson's disease,...
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