Article

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

2024-02-29

Abstract excerpt

The onset of protein conformation diseases is inextricably linked to aging. During aging, cellular protein quality control declines which results in diminished protein homeostasis (proteostasis). In model organisms, such as C. elegans and killifish, proteostatic decline with age has been linked to the onset of aggregation of proteins in wild-type animals, observed through detergent-insoluble fractionation. Analys...

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Literature Corpus work: 25353c6c-768d-50a9-9784-de7927b58a3e
DOI: 10.1101/2024.02.28.582597

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