Article
Widespread Proteome Remodeling and Aggregation in Aging C. elegans.
Cell - 7 May 2015
Walther Dirk M, Kasturi Prasad, Zheng Min, Pinkert Stefan, Vecchi Giulia, Ciryam Prajwal, Morimoto Richard I, Dobson Christopher M, Vendruscolo Michele, Mann Matthias, Hartl F Ulrich
Abstract excerpt
Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during aging, resulting in a severe proteome imbalance. These changes are reduced in the long-lived daf-2...
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