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Proteostasis and longevity: when does aging really begin?

3 Feb 2014

Abstract excerpt

Aging is a complex process regulated by multiple cellular pathways, including the proteostasis network. The proteostasis network consists of molecular chaperones, stress-response transcription factors, and protein degradation machines that sense and respond to proteotoxic stress and protein misfolding to ensure cell viability. A loss of proteostasis is associated with aging and age-related disorders in diverse...

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PMID: 24592319
DOI: 10.12703/p6-7

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