Article

Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in C. elegans via degradation of Intrinsically Disordered Proteins

2024-04-06

Abstract excerpt

Age-related proteinopathies, including Alzheimer’s and Parkinson’s disease, are driven by the toxic accumulation of misfolded proteins, particularly intrinsically disordered proteins (IDPs), that overwhelm cellular proteostasis. The proteasome is responsible for the clearance of these proteins, but it is unclear why it fails to do so in these diseases. Here, we report a novel strategy employing a C. elegans model...

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Literature Corpus work: 092f3feb-c900-55a5-bbe3-776210af0f9d
DOI: 10.1101/2024.04.04.588128

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Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in C. elegans via degradation of Intrinsically Disordered ProteinsDOI 10.1101/2024.04.04.588128Read

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Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in <i>C. elegans</i> via degradation of Intrinsically Disordered Proteins

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