Article
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in <i>C. elegans</i>
2018-09-14
Abstract excerpt
Reduced protein homeostasis and increased protein instability is a common feature of aging. Yet it remains unclear whether protein instability is a cause of aging. In neurodegenerative diseases and amyloidoses, specific proteins self-assemble into amyloid fibrils and accumulate as pathological solid aggregates in a variety of tissues. More recently, widespread protein aggregation has been described during normal a...
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Identifiers and source
- Literature Corpus work
- 3dcc11e7-7627-512c-ab72-5c2b6aa07d79
- DOI
- 10.1101/417873