Article

Amyloid β accelerates age-related proteome-wide protein insolubility

2023-07-15

Abstract excerpt

Loss of proteostasis is a highly conserved feature of aging across model organisms and typically results in the accumulation of insoluble protein aggregates. Protein insolubility is a central feature of major age-related neurodegenerative diseases, including Alzheimer’s Disease (AD), where hundreds of insoluble proteins associate with aggregated amyloid beta (Aβ) in senile plaques. Moreover, proteins that become i...

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Literature Corpus work: fc58383b-9f16-58c2-89ae-8f236349fa2a
DOI: 10.1101/2023.07.13.548937

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