Article
Progressive disruption of cellular protein folding in models of polyglutamine diseases.
Science (New York, N.Y.) - 10 Mar 2006
Gidalevitz Tali, Ben-Zvi Anat, Ho Kim H, Brignull Heather R, Morimoto Richard I
Abstract excerpt
Numerous human diseases are associated with the chronic expression of misfolded and aggregation-prone proteins. The expansion of polyglutamine residues in unrelated proteins is associated with the early onset of neurodegenerative disease. To understand how the presence of misfolded proteins leads to cellular dysfunction, we employed Caenorhabditis elegans polyglutamine aggregation models. Here, we find that...
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