Article

Heterogeneity in heat shock response dynamics caused by translation fidelity decline and proteostasis collapse

2019-10-30

Abstract excerpt

Genetics, environment, and stochasticity influence the rate of ageing in living organisms. Individual Caenorhabditis elegans that are genetically identical and cultured in the same environment have different lifespans, suggesting a significant role of stochasticity in ageing. We have developed a novel microfluidic methodology to measure heat-shock response as a surrogate marker for heterogeneity associated with l...

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Literature Corpus work: d3956525-5250-517e-945a-d5d3875269eb
DOI: 10.1101/822072

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