Article

Inhibition of ApoE4 Endocytosis with LDLR-LA Peptides

2026-05-22

Abstract excerpt

The Apolipoprotein E4 (ApoE4) genotype is the most significant genetic risk factor for late-onset Alzheimer’s disease (AD). A key driver of ApoE4 cellular toxicity is the endo-lysosomal burden resulting from the excessive receptor-mediated uptake of ApoE4 lipoparticles. The high-affinity interaction between lipidated ApoE4 and the Low-Density Lipoprotein Receptor (LDLR) saturates the cellular degradation machinery...

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Literature Corpus work: 9cc4efff-03a7-5a23-a2f4-da6a1c4fba72
DOI: 10.64898/2026.05.20.726622

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