Article

Domino-like Effect of C112R Mutation on ApoE4 Aggregation and Its Reduction by Alzheimer’s Disease Drug Candidate

2022-10-09

Abstract excerpt

<h4>Background</h4> Apolipoprotein E (ApoE) ε4 genotype is the most prevalent risk factor for late-onset Alzheimer’s Disease (AD). Although ApoE4 differs from its non-pathological ApoE3 isoform only by the C112R mutation, the molecular mechanism of its proteinopathy is unknown. <h4>Methods</h4> Here, we reveal the molecular mechanism of ApoE4 aggregation using a combination of experimental and computational tech...

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Literature Corpus work: 08f13751-bcb5-59d2-9cc9-ddaa7cf8e2c5
DOI: 10.1101/2022.10.09.511473

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