Article

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling

2021-05-20

Abstract excerpt

<h4>ABSTRACT</h4> Sortilin is a receptor for neuronal uptake of apolipoprotein E. Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain. This neuroprotective pathway works with apoE3 but is lost with apoE4, the main risk factor for Alzheimer’s disease (AD). Here, we elucidated steps in c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fac6ab50-0b75-569b-8581-330e5bd37b07
DOI: 10.1101/2021.05.20.444938

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signalingDOI 10.1101/2021.05.20.444938Read

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signalingSemantic proximity Read

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.Semantic proximity Read

Cholesterol and matrisome pathways dysregulated in human <i>APOE</i> ε4 gliaSemantic proximity Read

APOE3 Christchurch is associated with sphingolipids recycling and glial lipid remodeling in autosomal dominant Alzheimer’s diseaseSemantic proximity Read

The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of ApoE4 in Alzheimer DiseaseSemantic proximity Read

APOE2, E3 and E4 differentially modulate cellular homeostasis, cholesterol metabolism and inflammatory response in isogenic iPSC-derived astrocytesSemantic proximity Read

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.Semantic proximity Read

ApoE Lipidation as a Therapeutic Target in Alzheimer’s DiseaseSemantic proximity Read

Beyond the CNS: The many peripheral roles of APOE.Semantic proximity Read

Protective ApoE variants support neuronal function by extracting peroxidated lipidsSemantic proximity Read

The Contributions of the Endolysosomal Compartment and Autophagy to APOEɛ4 Allele-Mediated Increase in Alzheimer's Disease Risk.Semantic proximity Read

<i>APOE</i> genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamicsSemantic proximity Read