Article

XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 Binding

2026-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Apolipoprotein E ( APOE ) and Triggering Receptor Expressed on Myeloid cells 2 ( TREM2 ) are the two strongest genetic risk factors of late-onset Alzheimer’s disease. ApoE binds to the low-density lipoprotein receptor (LDLR) to facilitate the uptake of ApoE-lipoprotein particles. TREM2 is a cell surface receptor expressed on microglia in the brain. The activation of TREM2 is essential for micr...

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Literature Corpus work: 83f90d32-9522-542c-8a1e-178573ba13e2
DOI: 10.64898/2026.04.23.720433

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