Article

The Ligand Preference of LRP1 is Regulated by O-glycans

2025-10-23

Abstract excerpt

Low-density lipoprotein receptor (LDLR) and LDLR-related proteins (LRPs) are endocytic receptors serving as essential physiological regulators of multiple processes including cholesterol clearance, protein reabsorption and neuronal protein trafficking. We originally discovered O-glycans in linkers of the ligand-binding domains of LDLR/LRP receptors and showed that these play critical roles for uptake of LDL by LDL...

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Literature Corpus work: cf8754d5-c459-5328-8b39-37bc30b48e81
DOI: 10.1101/2025.10.23.684103

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