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Article

The Contributions of the Endolysosomal Compartment and Autophagy to APOEɛ4 Allele-Mediated Increase in Alzheimer's Disease Risk.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Asiamah Ernest Amponsah, Feng Baofeng, Guo Ruiyun, Yaxing Xu, Du Xiaofeng, Liu Xin, Zhang Jinyu, Cui Huixian, Ma Jun

Abstract excerpt

Apolipoprotein E4 (APOE4), although yet-to-be fully understood, increases the risk and lowers the age of onset of Alzheimer's disease (AD), which is the major cause of dementia among elderly individuals. The endosome-lysosome and autophagy pathways, which are necessary for homeostasis in both neurons and glia, are dysregulated even in early AD. Nonetheless, the contributory roles of these pathways to developing...

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Source

Identifiers

PMID: 38306054
DOI: 10.3233/JAD-230658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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