Article

The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of ApoE4 in Alzheimer Disease

2022-12-07

Abstract excerpt

<h4>Background: </h4> Apolipoprotein E4 (apoE4) is the most prevalent genetic risk factor of Alzheimer’s disease (AD). Several studies suggest that the binding of apoE4 to its receptors (i.e., apoER2 and LRP-1) is associated with the internalization of the receptors and their accumulation in intracellular compartments. Importantly, this phenomenon also occurs with other, non-apoE, receptors. These observations lea...

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Literature Corpus work: ee26ee63-17e8-58ea-80a6-7f4f052e448f
DOI: 10.21203/rs.3.rs-2343150/v1

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