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ApoE Lipidation as a Therapeutic Target in Alzheimer’s Disease

1 Sept 2020

Abstract excerpt

Apolipoprotein E (APOE) is the major cholesterol carrier in the brain, affecting various normal cellular processes including neuronal growth, repair and remodeling of membranes, synaptogenesis, clearance and degradation of amyloid β (Aβ) and neuroinflammation. In humans, the APOE gene has three common allelic variants, termed E2, E3, and E4. APOE4 is considered the strongest genetic risk factor for Alzheimer’s...

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PMID: 32882843
DOI: 10.3390/ijms21176336

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