Article

AAV-based temporal APOE4-to-APOE2 replacement reveals rebound adaptation and RAB24-mediated Aβ and cholesterol dysregulation

2025-07-11

Abstract excerpt

APOE-targeted gene therapy offers a promising strategy for modifying Alzheimer’s disease (AD) risk, yet the temporal dynamics and context-dependent effects of APOE isoform modulation remain poorly defined. Here, we developed a rapid AAV-based platform enabling inducible in vivo replacement of APOE4 with APOE2. In 5×FAD mice, sustained APOE4 expression exacerbated cognitive decline, Aβ deposition (parenchymal and v...

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Literature Corpus work: f702254f-a7a9-50a9-868e-2b07f0bb5463
DOI: 10.1101/2025.07.08.663694

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