Article

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction

2023-10-02

Abstract excerpt

ApoE4 is the primary risk factor for Alzheimer Disease (AD). Early AD pathological events first affect the neuronal endolysosomal system, which in turn causes neuronal protein aggregation and cell death. Despite the crucial influence of lysosomes upon AD pathophysiology, and that apoE4 localizes to lysosomes, the influence of apoE4 on lysosomal function remains unexplored. We find that expression of apoE4 in neuro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f0d328f-aa9a-59b6-8bd9-355f3689e1b5
DOI: 10.1101/2023.10.02.560519

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunctionDOI 10.1101/2023.10.02.560519Read

The Contributions of the Endolysosomal Compartment and Autophagy to APOEɛ4 Allele-Mediated Increase in Alzheimer's Disease Risk.Semantic proximity Read

Phospholipase D3 regulates lysosomal morphology, biogenesis, and function in neuronsSemantic proximity Read

Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Semantic proximity Read

APOE4 disrupts the central dogma by arresting neuronal proteome dynamicsSemantic proximity Read

Neurodegenerative lysosomal disorders: A continuum from development to late ageSemantic proximity Read

A Review of APOE Genotype-Dependent Autophagic Flux Regulation in Alzheimer's Disease.Semantic proximity Read

The neuronal endosomal-lysosomal system in Alzheimer's diseaseSemantic proximity Read

Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkersSemantic proximity Read

Broken Balance: Emerging Cross-Talk Between Proteostasis and Lipostasis in Neurodegenerative DiseasesSemantic proximity Read

Defective Lysosomal Lipid Catabolism as a Common Pathogenic Mechanism for Dementia.Semantic proximity Read

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factorsSemantic proximity Read

A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's DiseaseSemantic proximity Read