Article

Recombinant sialylated ApoE2 suppresses ApoE4 and sex-specifically strengthens brain metabolism and cognition in ApoE4 mice

2026-08-04

Abstract excerpt

Human APOE4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), whereas the relatively rare APOE2 confers exceptional protection. This study examines whether recombinant ApoE2 protein can therapeutically leverage this genetic advantage to strengthen aging brains at risk for AD. We produced recombinant human ApoE2 (rhApoE2) using the FreeStyle 293-F system, yielding rhApoE2 with extensiv...

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Literature Corpus work: b34ac6dd-8b90-59b5-b648-9e291b8318f4
DOI: 10.64898/2026.07.30.741628

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Recombinant sialylated ApoE2 suppresses ApoE4 and sex-specifically strengthens brain metabolism and cognition in ApoE4 miceDOI 10.64898/2026.07.30.741628Read

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