Article

IL-10 inhibits STAT1-dependent macrophage accumulation during microbiota-induced colitis

2022-09-03

Abstract excerpt

Loss of IL-10R function leads to severe early onset colitis and in murine models is associated with the accumulation of immature inflammatory colonic macrophages. We have shown that IL-10R-deficient colonic macrophages exhibit increased STAT1-dependent gene expression, suggesting that IL-10R-mediated inhibition of STAT1 signaling in newly recruited colonic macrophages might interfere with the development of an inf...

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Literature Corpus work: 9c5b45f5-b89d-5c88-b432-e3e1507a6ab3
DOI: 10.1101/2022.09.01.505766

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