Article

HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine

2022-03-11

Abstract excerpt

Patients with mutations in HOIL1 experience a complex immune disorder including intestinal inflammation. To investigate the role of HOIL1 in regulating intestinal inflammation, we employed a mouse model of HOIL1 deficiency. The ileum of Hoil1 −/− mice displayed features of type 2 inflammation including tuft cell and goblet cell hyperplasia, and elevated expression of Il13 , Il5 and Il25 mRNA. Inflammation pe...

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Literature Corpus work: c8eaf666-904d-556b-ab37-fb1845bd6576
DOI: 10.1101/2022.03.09.483650

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