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Modulation of β-Catenin promotes WNT expression in macrophages and mitigates intestinal injury

11 Feb 2025

Abstract excerpt

Macrophages are the major source of WNT ligands. However, the regulation of WNT expression in macrophages has not been studied. In the present study, we have discovered that activation of canonical β-Catenin signaling suppresses WNT expression in macrophages. EVs from these pre-conditioned macrophages promoted intestinal stem cell regeneration and mitigated intestinal injury. ChIP-seq analysis and validation...

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PMID: 39934819
DOI: 10.1186/s12964-025-02065-7

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