Article
Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.
Gastroenterology - 1 Dec 2016
Shouval Dror S, Biswas Amlan, Kang Yu Hui, Griffith Alexandra E, Konnikova Liza, Mascanfroni Ivan D, Redhu Naresh S, Frei Sandra M, Field Michael, Doty Andria L, Goldsmith Jeffrey D, Bhan Atul K, Loizides Anthony, Weiss Batia, Yerushalmi Baruch, Yanagi Tadahiro, Lui Xiuli, Quintana Francisco J, Muise Aleixo M, Klein Christoph, Horwitz Bruce H, Glover Sarah C, Bousvaros Athos, Snapper Scott B
Abstract excerpt
Interleukin 10 receptor (IL10R)-deficient mice develop spontaneous colitis and, similarly, patients with loss-of-function mutations in IL10R develop severe infant-onset inflammatory bowel disease. Loss of IL10R signaling in mouse and human macrophages is associated with increased production of interleukin 1β. We demonstrated that innate immune production of IL1β mediates colitis in IL10R-deficient mice. Transfer...
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