Article

Type I interferon signaling promotes mucosal inflammation in murine models of colitis

2026-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Type I interferons (IFN-Is) play a critical role in innate immunity, modulating the host response. While dysregulated IFN-I signaling has been implicated in autoimmune and infectious disorders, its role in inflammatory bowel disease (IBD) remains unclear. In this study, we extensively assessed the function of IFN-I signaling in human IBD and murine models of colitis. Expression of IFN-I signatur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 952c3a19-7a3e-54c6-a467-fd0b3a2586e8
DOI: 10.64898/2026.03.02.709022

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type I interferon signaling promotes mucosal inflammation in murine models of colitisDOI 10.64898/2026.03.02.709022Read

Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration.Semantic proximity Read

Inflammatory bowel disease pathobiology: the role of the interferon signatureSemantic proximity Read

Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer.Semantic proximity Read

The IBD-associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulationSemantic proximity Read

A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epitheliumSemantic proximity Read

Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responsesSemantic proximity Read

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epitheliumSemantic proximity Read

DNAM-1 immunoreceptor integrates innate and adaptive immune programs to drive intestinal inflammationSemantic proximity Read

A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasisSemantic proximity Read

A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammationSemantic proximity Read

Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseasesSemantic proximity Read

Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitisSemantic proximity Read