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Generation and Phenotypic Analysis of the IL-10RAR104W/R104W Mouse Model.

Inflammatory bowel diseases - 1 Nov 2025

Cao Xiaoya, Zeng Zhiyang, Cao Xiya, He Youyuan, Wang Liren, Li Dali, Zhang Xueli

Abstract excerpt

BACKGROUND: Very-early-onset inflammatory bowel disease (VEO-IBD) is a form of IBD that manifests in infants and young children, with a significant proportion of them carrying interleukin 10 receptor alpha (IL-10RA) mutations. Despite the increasing incidence rate, the pathogenesis of VEO-IBD remains elusive, and treatment options are limited. The utilization of a humanized mouse model holds promise for further...

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Colitis
CRISPR-Cas Systems
Disease Models, Animal
Inflammatory Bowel Diseases
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

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PMID: 41017740
DOI: 10.1093/ibd/izaf099
PMCID: PMC12638067

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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