Article
IL-10 control of CD11c+ myeloid cells is essential to maintain immune homeostasis in the small and large intestine.
Oncotarget - 31 May 2016
Girard-Madoux Mathilde J H, Ober-Blöbaum Juliane L, Costes Léa M M, Kel Junda M, Lindenbergh-Kortleve Dicky J, Brouwers-Haspels Inge, Heikema Astrid P, Samsom Janneke N, Clausen Björn E
Abstract excerpt
Although IL-10 promotes a regulatory phenotype of CD11c+ dendritic cells and macrophages in vitro, the role of IL-10 signaling in CD11c+ cells to maintain intestinal tolerance in vivo remains elusive. To this aim, we generated mice with a CD11c-specific deletion of the IL-10 receptor alpha (Cd11ccreIl10rafl/fl). In contrast to the colon, the small intestine of Cd11ccreIl10rafl/fl mice exhibited spontaneous crypt...
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