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Article

Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation.

American journal of physiology. Gastrointestinal and liver physiology - 1 Dec 2015

Papadakis Konstantinos A, Krempski James, Svingen Phyllis, Xiong Yuning, Sarmento Olga F, Lomberk Gwen A, Urrutia Raul A, Faubion William A

Abstract excerpt

Krüppel-like factor (KLF)-10 is an important transcriptional regulator of TGF-β1 signaling in both CD8(+) and CD4(+) T lymphocytes. In the present study, we demonstrate a novel role for KLF10 in the regulation of TGFβRII expression with functional relevance in macrophage differentiation and activation. We first show that transfer of KLF10(-/-) bone marrow-derived macrophages into wild-type (WT) mice leads to...

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Identifiers

PMID: 26472224
DOI: 10.1152/ajpgi.00309.2015
PMCID: PMC4669350

Genes

KLF10
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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