Chronic exposure to interleukin-10 drives inflammaging and accelerated tissue senescence

Abstract excerpt

<title>Abstract</title> <p>Interleukin (IL)-10, a major anti-inflammatory cytokine, can paradoxically have pro-inflammatory activities, which limits the efficacy of IL-10-based therapies. We previously showed that in vivo exposure to therapeutic doses of IL-10 reprograms T cells and promotes interferon (IFN)-γ-mediated emergency myelopoiesis. Here, we show that chronic IL-10 elevation in mice reprograms CD4+ and...

Topics

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• Aging
• Cause of Death
• Cross-Sectional Studies
• Cytokines
• Disease Models, Animal
• Homeostasis
• Inflammation
• Phenotype

Identifiers and source

Literature Corpus work

8c75b44d-1838-5123-a16c-e9b207e05510

DOI

10.21203/rs.3.rs-8603195/v1