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The Transcription Factor RORα Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection

1 Nov 2019

Abstract excerpt

Abstract Innate lymphoid cells (ILCs) are critical for host defense and tissue repair but can also contribute to chronic inflammatory diseases. The transcription factor RORα is required for ILC2 development but is also highly expressed by other ILC subsets where its function remains poorly defined. We previously reported that Rorasg/sg bone marrow chimeric mice (C57BL/6J) were protected from Salmonella-induced...

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PMID: 31676672
DOI: 10.4049/jimmunol.1900781

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