Article

Reduced gene templates for supervised analysis of scale-limited CRISPR-Cas9 fitness screens

2022-03-01

Abstract excerpt

<h4>Summary</h4> Pooled genome-wide CRISPR-Cas9 screens are furthering our mechanistic understanding of human biology and have allowed us to identify new oncology therapeutic targets. Scale-limited CRISPR-Cas9 screens – typically employing guide RNA libraries targeting subsets of functionally related genes, individual biological pathways, or portions of the druggable genome – constitute an optimal setting for inv...

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Literature Corpus work: 9c293572-2f60-5a36-b14c-392a5e96dfad
DOI: 10.1101/2022.02.28.482271

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