Article

A benchmark of computational methods for correcting biases of established and unknown origin in CRISPR-Cas9 screening data

2024-01-31

Abstract excerpt

CRISPR-Cas9 dropout screens stand as formidable tools for investigating biology with unprecedented precision and scale. One of their principal applications involves probing large panels of immortalised human cancer cell lines for viability reduction responses upon systematic genetic knock-out at a genome-wide level, to identify novel cancer dependencies and therapeutic targets. However, biases in CRISPR-Cas9 scree...

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Literature Corpus work: 12f066b7-770a-5e99-9c64-ea6e64aca899
DOI: 10.1101/2024.01.30.577980

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