Article

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

2014-03-17

Abstract excerpt

Technological advancement has opened the door to systematic genetics in mammalian cells. Genome-scale loss-of-function screens can assay fitness defects induced by partial gene knockdown, using RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can reveal the basic blueprint required for cellular proliferation. Moreover, comparing healthy to cancerous tissue can uncover genes t...

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Literature Corpus work: 2ee0538c-30c6-569c-b339-b893d31ffbc8
DOI: 10.1101/003327

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