Article

CoRe: A robustly benchmarked R package for identifying core-fitness genes in genome-wide pooled CRISPR-Cas9 screens

2021-05-26

Abstract excerpt

CRISPR-Cas9 genome-wide screens are being increasingly performed, allowing systematic explorations of cancer dependencies at unprecedented accuracy and scale. Identifying from these screens the genes that are essential for cell survival invariantly across tissues, conditions, and genomic-contexts (core-fitness genes), is of paramount importance to assess the safety profile of candidate therapeutic targets and for...

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Literature Corpus work: b19a4c91-17f3-5198-8b8e-5fd8efa44191
DOI: 10.1101/2021.05.25.445610

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