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O-GlcNAcylation and low glycolysis underpin Th2 polarization by dendritic cells

2026-02-05

Abstract excerpt

Activation of dendritic cells (DCs) is dependent on rewiring of their cellular metabolism. However, the metabolic requirements for DCs to prime T helper 2 (Th2) responses are still poorly understood. Using unbiased transcriptomics and non-targeted metabolomics we find that helminth antigen-conditioned human DCs suppress glycolysis while increasing hexosamine biosynthesis to fuel protein O-GlcNAcylation. Functional...

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Literature Corpus work
9bc693a8-202e-5467-a59c-c975f90626ca
DOI
10.64898/2026.02.03.703465
Open publication

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O-GlcNAcylation and low glycolysis underpin Th2 polarization by dendritic cellsDOI 10.64898/2026.02.03.703465
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