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An atlas of transcriptomic changes in human immune cells driven by 364 endogenous and gut-microbiota-derived metabolites

22 Apr 2025

Abstract excerpt

Metabolites, particularly those derived from gut microbiota, play crucial roles in modulating immune responses, but the impact of most metabolites on immune cells remains unexplored. To systematically investigate the effect of metabolites on immune cells, we treated peripheral blood mononuclear cells (PBMCs) with 364 endogenous and gut microbiota metabolites and analyzed their impact on the PBMC transcriptome...

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PMID: 40258971
DOI: 10.1038/s41598-025-98781-8

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