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The Metabolic Requirements of Th2 Cell Differentiation

27 Sept 2019

Abstract excerpt

T cells differentiate into a number of specialized T helper (Th) cell subsets. Th2 cells are central players in immunity to helminths and are implicated in mediating the inflammatory pathology associated with allergies. The differentiation of Th2 cells is dependent on transcription factors such as GATA3 and STAT6, which prime Th2 cells for the secretion of interleukin- (IL-) 4, IL-5, and IL-13. Several lines of...

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PMID: 31611881
DOI: 10.3389/fimmu.2019.02318

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