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Mgl2 <sup>+</sup> cDC2 triggering of fungal allergic inflammation depends on a spore induced glycolytic shift fuelled by local availability of glucose

2025-07-18

Abstract excerpt

Fungal spores are a major cause of severe asthmatic disease. However, the precise events that cause individuals to become sensitised to spores are poorly understood. Mgl2 + type 2 conventional dendritic cells (Mgl2 + cDC2s) are critical in coordinating allergic airway inflammation in mice following repeated exposure to inhaled spores. Yet, whether these DCs are directly acquiring spores from the airway, and the...

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Literature Corpus work
efa5c12d-0867-5ae4-9f00-74bfdf72354d
DOI
10.1101/2025.07.13.664342
Open publication

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Mgl2 <sup>+</sup> cDC2 triggering of fungal allergic inflammation depends on a spore induced glycolytic shift fuelled by local availability of glucoseDOI 10.1101/2025.07.13.664342
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