Article

Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation

2019-11-05

Abstract excerpt

<h4>Summary</h4> Diabetes mellitus (DM) significantly increases the risk for cancer and cancer progression. Hyperglycemia is the defining characteristic of DM and tightly correlates with a poor prognosis in cancer patients. The hexosamine biosynthetic pathway (HBP) is emerging as a pivotal cascade linking high glucose, tumor progression and impaired immune function. Here we show that enhanced glucose flow through...

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Literature Corpus work: 43f54b7e-4195-5703-b069-3a106407c3b2
DOI: 10.1101/831610

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