Article

APOE regulates the transport of GM1

2024-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Apolipoprotein E (APOE) is responsible for lipid transport, including cholesterol transport and clearance. While the ε4 allele of APOE (APOE4) is associated with a significant genetic risk factor for late-onset Alzheimer’s disease (AD), no mechanistic understanding of its contribution to AD etiology has been established yet. In addition to cholesterol, monosialotetrahexosylganglioside (GM1) is a...

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Literature Corpus work: 98dbd47b-d13f-53da-835d-e65c0a2f6a45
DOI: 10.1101/2024.04.02.587789

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