Article

APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size

2023-04-29

Abstract excerpt

The E4 variant of APOE strongly predisposes individuals to late-onset Alzheimer’s disease. We demonstrate that in response to neutral lipid synthesis, apolipoprotein E (APOE) in astrocytes can avoid translocation into the ER lumen and traffic to lipid droplets (LDs) via membrane bridges at ER-LD contacts. APOE knockdown promotes fewer, larger LDs containing more unsaturated triglyceride. This LD size distributi...

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Literature Corpus work: f1b47ca2-bd82-5958-a672-9a4427a5fd7b
DOI: 10.1101/2023.04.28.538740

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