Article

Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer’s disease pathology

2021-05-30

Abstract excerpt

<h4>BACKGROUND</h4> C-reactive protein (CRP) in peripheral inflammation is associated with increased Alzheimer’s disease (AD) risk in Apolipoprotein E4 (ApoE4), but not ApoE3 or E2, humans. It remains unknown whether peripheral monomeric CRP (mCRP) induces AD pathogenesis through some receptor of blood-facing endothelia in the brain in an ApoE genotype dependent fashion. <h4>METHODS</h4> We used human samples, A...

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Literature Corpus work: d1790494-14ea-5443-8e4c-e525314d7306
DOI: 10.1101/2021.05.30.446344

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Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer’s disease pathologyDOI 10.1101/2021.05.30.446344Read

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