Article

Lipidated ApoE is found in nanoscale proximity to Aβ aggregates in human Alzheimer brains

2026-06-03

Abstract excerpt

Apolipoprotein E ( APOE ) associates with amyloid plaques (Aβ) in Alzheimer disease (AD). The ε4 allele of apolipoprotein E ( APOE ε4) is the strongest genetic risk factor for sporadic AD and exacerbates Aβ plaque burden relative to APOE ε3 and APOE ε2. The majority of ApoE associates with multiple lipid classes to form lipoproteins both in the brain and the periphery. However, the lipidation status of Aβ plaq...

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Literature Corpus work: b9debb59-9937-5a70-9c79-6328537369b8
DOI: 10.64898/2026.05.30.729004

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