Article

Altered GM1 catabolism affects NMDAR-mediated Ca <sup>2+</sup> signaling at ER-PM junctions and increases synaptic spine formation

2023-07-11

Abstract excerpt

<h4>Summary</h4> Endoplasmic reticulum–plasma membrane (ER-PM) junctions mediate Ca 2+ flux across neuronal membranes. The properties of these membrane contact sites are defined by their lipid content, but little attention has been given to glycosphingolipids (GSLs). Here, we show that GM1-ganglioside, an abundant GSL in neuronal membranes, is integral to ER-PM junctions; it interacts with synaptic proteins/rece...

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Literature Corpus work: 8f34751f-cae5-5e4e-a059-692381b666ce
DOI: 10.1101/2023.07.10.548446

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Altered GM1 catabolism affects NMDAR-mediated Ca <sup>2+</sup> signaling at ER-PM junctions and increases synaptic spine formationDOI 10.1101/2023.07.10.548446Read

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