Article

APOE interacts with COX-2 on lipid droplets to modulate inflammatory lipid signaling

2026-06-10

Abstract excerpt

Alzheimer’s Disease (AD) is the leading cause of dementia worldwide. Expression of the E4 variant of apolipoprotein E ( APOE ) greatly increases individuals’ risk of developing AD. In response to lipogenesis in astrocytes, APOE can escape secretion and traffic to the cytoplasmic surface of lipid droplets (LDs), but protein interactors of APOE at the LD were unknown. Here we find that LD-localized APOE physically...

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Literature Corpus work: b9ef0f74-10ba-5f32-96e9-ce127bfbd193
DOI: 10.64898/2026.06.09.730852

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