Article

High-density lipoprotein mimetic peptide 4F ameliorates APOE4-associated lipid dysfunction in primary and iPSC-derived astrocytes and cerebral organoids

2025-12-18

Abstract excerpt

APOE is the greatest genetic risk factor for late-onset Alzheimer’s disease (AD). In humans, APOE has three isoforms: APOE2 (E2), APOE3 (E3), and APOE4 (E4); E4 increases AD risk, while E3 is neutral and E2 decreases risk. In the brain, APOE is predominantly produced by astrocytes, where it binds lipids to form HDL-like particles, and plays a central role in lipid homeostasis, Aβ clearance, and neuroimmune modulat...

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Literature Corpus work: 45c5c67d-daa9-5e1c-95ae-dc2dbd1f8ae7
DOI: 10.64898/2025.12.16.694774

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