Article

Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

2019-08-22

Abstract excerpt

Genome-wide mapping of chromatin interactions at high resolution remains experimentally and computationally challenging. Here we used a low-input “easy Hi-C” (eHi-C) protocol to map the 3D genome architecture in neurogenesis and brain tissues, and also developed an improved Hi-C bias-correction pipeline ( HiCorr ) enabling better identification of enhancer loops or aggregates at sub-TAD level. We compared ultra-d...

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Literature Corpus work: d8f3f831-0459-5df7-a9e9-c250fe291549
DOI: 10.1101/744540

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