Article

Enhanced Hi-C Capture Analysis reveals complex regulatory architecture at the <i>PICALM_EED</i> locus for Alzheimer’s disease

2026-02-17

Abstract excerpt

<h4>Objective</h4> Both the phosphatidylinositol binding clathrin assembly protein gene ( PICALM) and the embryonic ectoderm development gene ( EED) have been implicated as causal genes driving a genome-wide association for Alzheimer disease (AD) risk. We employed a new virtual approach using genome-wide chromatin interactions (Hi-C) called enhanced Hi-C Capture Analysis (eHiCA) to identify the genes and regula...

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Literature Corpus work: c2ee9c93-aab9-5fba-a068-85af579aa502
DOI: 10.64898/2026.02.14.705927

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