Article

Epigenome erosion in Alzheimer’s disease brain cells and induced neurons

2023-10-18

Abstract excerpt

<h4>ABSTRACT</h4> Late-onset Alzheimer’s disease (LOAD) is typically sporadic, correlated only to advanced age, and has no clear genetic risk factors. The sporadic nature of LOAD presents a challenge to understanding its pathogenesis and mechanisms. Here, we comprehensively investigated the epigenome of LOAD primary entorhinal cortex brain tissues via single-cell multi-omics technologies, simultaneously capturing...

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Literature Corpus work: 2ffc92df-495c-5a7a-83b6-b72e7c9fe6a4
DOI: 10.1101/2023.10.15.562394

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